| 1 | GRUPOFARMA DEL ECUADOR S.A. | US$ 38.114.399 | US$ 481.794 | 111 | Pichincha |
| 2 | FRESENIUS KABI S.A. | US$ 22.317.903 | US$ 735.484 | 125 | Guayas |
| 3 | HERBALIFE DEL ECUADOR S.A. | US$ 32.600.405 | US$ 2.467.869 | 29 | Pichincha |
| 4 | BALANCEADOS NOVA S.A. BALNOVA | US$ 27.156.695 | US$ -23.711.993 | 18 | Guayas |
| 5 | ESVELTS S.A. | US$ 16.897.429 | US$ 270.706 | 198 | Guayas |
| 6 | LABMAC S.A. | US$ 8.811.391 | US$ 325.803 | 108 | Guayas |
| 7 | 4LIFE RESEARCH ECUADOR, LLC | US$ 10.667.825 | US$ -37.538 | 39 | Pichincha |
| 8 | ONLYNAT LABORATORIOS DEL ECUADOR S.A. | US$ 4.651.601 | US$ 260.549 | 27 | Guayas |
| 9 | GYKORMED S.A. | US$ 3.019.086 | US$ 124.821 | 12 | Guayas |
| 10 | NUTRIFIT S.A. | US$ 4.015.129 | US$ 277.095 | 14 | Guayas |
| 11 | LABORATORIOS BIOINDUSTRIA S.A. LABIOSA | US$ 1.436.404 | US$ 2.657 | 30 | Guayas |
| 12 | SALUDYFITNESS S.A. | US$ 4.597.440 | US$ -12.925 | 79 | Guayas |
| 13 | DISMOPRA S.A. | US$ 1.680.135 | US$ 66.935 | 6 | Guayas |
| 14 | YOUNGLIVING ECUADOR S.A.S. | US$ 1.049.851 | US$ -432.770 | 17 | Guayas |
| 15 | FOREVER-LIVING PRODUCTOS DEL ECUADOR SOCIEDAD ANÓNIMA | US$ 3.818.532 | US$ 10.955 | 13 | Guayas |
| 16 | KOOM SPORTS S.A.S. | US$ 1.826.376 | US$ 286.965 | 6 | Guayas |
| 17 | PRODUCTOS NATURALES MILINARIOS PRONATMIL S.A. | US$ 1.549.813 | US$ 26.620 | 12 | Guayas |
| 18 | SIGNIA LOGISTIC-SOLUTIONS DEL ECUADOR S.A. | US$ 1.756.821 | US$ -1.111 | 63 | Pichincha |
| 19 | ISC INTEGRITY SOLUTIONS & CONSULTING CIA. LTDA. | US$ 2.333.167 | US$ 188.834 | 5 | Guayas |
| 20 | ADICANEX S.A. | US$ 82.480 | US$ 2.282 | 4 | Guayas |
| 21 | LUAV VITAL S.A.S. | US$ 1.400.196 | US$ 120.880 | 4 | Manabi |
| 22 | BAP STORE B.A.P S.A. | US$ 1.842.130 | US$ 28.738 | 2 | Pichincha |
| 23 | MUNDO VERDE MUV CIA .LTDA. | US$ 587.489 | US$ 14.726 | 6 | Guayas |
| 24 | VACONCORP S.A. | US$ 990.184 | US$ 14.969 | 10 | Guayas |
| 25 | NATURAL FACTORS S.A.S. | US$ 691.579 | US$ -255,4 | 8 | Guayas |
| 26 | LABORATORIOS DEL PACIFICO PACIFICLAB S.A.S. | US$ 764.573 | US$ 9.398 | 6 | Manabi |
| 27 | UNIVERSY DEL ECUADOR UNIVERSYEC S.A. | US$ 184.010 | US$ 25.676 | 9 | Guayas |
| 28 | MUNDO SANO Y VERDE S.A. MUSANVERD | US$ 536.096 | US$ 60.180 | 2 | Los Rios |
| 29 | VVISIONLASER S.A. | US$ 0 | US$ 0 | 3 | Guayas |
| 30 | FILTANET S.A. | US$ 525.254 | US$ 8.866 | 10 | Pichincha |
| 31 | NATURALESMEJOR S.A. | US$ 984.508 | US$ 2.827 | 23 | Guayas |
| 32 | DISTRISALUD S.A. | US$ 746.271 | US$ 136,8 | 2 | Pichincha |
| 33 | LEGACYECUADOR S.A.S. | US$ 680.813 | US$ -3.307 | 5 | Imbabura |
| 34 | HOMEOPATICOS NATURALES HOMEONATURA SOCIEDAD ANONIMA | US$ 882.483 | US$ 16.676 | 3 | Pichincha |
| 35 | VITALCOMCOL COMMERCE S.A.S. | US$ 759.335 | US$ 31.313 | 9 | Pichincha |
| 36 | JOLOMAGRAM CIA.LTDA. | US$ 762.661 | US$ 376,2 | 8 | Pichincha |
| 37 | JUPELI C.A. | US$ 0 | US$ 0 | 1 | Pichincha |
| 38 | VIDADIVINA S.A. | US$ 501.108 | US$ 91.548 | 6 | Pichincha |
| 39 | OVOLETEC S.A. | US$ 100.000 | US$ 718,2 | 3 | Guayas |
| 40 | XIAKISH S.A. | US$ 115.651 | US$ 22.291 | 5 | Guayas |
| 41 | ANCESTRALES ECUADOR S.A.S. | US$ 714.652 | US$ 50.327 | 4 | Pichincha |
| 42 | CAMPOS IMPORTADORES DE PRODUCTOS NATURALES NATUCAM S.A. | US$ 521.397 | US$ 45.521 | 4 | Guayas |
| 43 | SHAJANA S.A. | US$ 234.466 | US$ 29.616 | 4 | Imbabura |
| 44 | TEOMA DEL ECUADOR S.A. | US$ 364.297 | US$ -423.361 | 8 | Pichincha |
| 45 | TENDO S.A. | US$ 0 | US$ 0 | 4 | Guayas |
| 46 | DULCAMARE S.A.S. | US$ 592.645 | US$ 24.477 | 14 | Guayas |
| 47 | ZONFOCUS S.A. | US$ 405.421 | US$ 3.740 | 6 | Guayas |
| 48 | BIO NATURA CORPUS PLUS S.A. BIONACORP | US$ 310.476 | US$ 12.308 | 14 | Guayas |
| 49 | ACTIVZ ECUADOR CIA. LTDA. | US$ 404.150 | US$ 577,4 | 3 | Guayas |
| 50 | SALUD INTEGRAL S. A. SALUINSA | US$ 577.373 | US$ -16.949 | 3 | Guayas |
| 51 | SOLAR ENERGY SOLGYS S.A. | US$ 440.566 | US$ 851,1 | 4 | Guayas |
| 52 | BIOROZMED S.A.S. | US$ 229.335 | US$ 100.726 | 1 | Santo Domingo De Los Tsachilas |
| 53 | COMASI ECUADOR S.A.S. | US$ 397.889 | US$ 17.348 | 5 | Pichincha |
| 54 | NUTRAMEDIX LABORATORIOS DEL ECUADOR S.A. | US$ 213.825 | US$ 7.850 | 6 | Guayas |
| 55 | RUIZ OÑOS PHARMA CIA. LTDA. | US$ 300.743 | US$ -39.703 | 3 | Pichincha |
| 56 | HEALTH ECUADOR S.A. HEALECUS | US$ 27.970 | US$ 0 | 4 | Guayas |
| 57 | VANNIER ECUADOR S.A. | US$ 356.957 | US$ 5.614 | 5 | Pichincha |
| 58 | YIN S.A. | US$ 368.800 | US$ 10.561 | 4 | Guayas |
| 59 | WORLDFIT S.A. | US$ 283.031 | US$ 13.153 | 2 | Guayas |
| 60 | WAYRA MIKUNA SÚPER FOODS S.A.S. | US$ 333.522 | US$ 2.568 | 8 | Pichincha |